Chronic liver disease refers to disease of the liver which had lasted over a period of 6 months and consists of a wide range of liver pathologies. Acute liver disease may develop over days or weeks.  Both chronic and acute liver disease can lead to liver failure. The main causes of liver failure are:

· Cirrhosis  (scarring of the liver).

· Different types of viral infections such as hepatitis B and C, yellow fever, or cytomegalovirus.

· Intakes of alcohol, drugs and toxic substances that may damage the liver

· Metabolic problems such as fatty liver or Wilson's Disease.

· Autoimmune disorders.

Most patients remain asymptomatic until signs and symptoms appear as a consequence of decompensation

Gynecomastia, or enlargement of men breast can be a normal physiological phenomenon or a sign of an underlying cause as a liver disease.

Abdominal pain may occur in the right upper quadrant of the abdomen.