No definitive treatment regimens have been determined.

Antibiotics are the primary treatment and can cure most cases of Lyme disease. The most appropriate antibiotic treatment depends upon the patient and the stage of the disease. Oral antibiotics may be sufficient for early stages of non-disseminated infection.

At the end of the treatment, some symptoms may still last. This is called post-Lyme disease syndrome (PLDS). The cause of these symptoms is not known, but they are not related to an ongoing infection with the bacteria.